Type 1 Diabetes U S News and World Report
Overview
Diabetes is a disease in which the body is unable to produce or properly use and store glucose, a form of sugar. Glucose backs up in the bloodstream, causing one's blood glucose (sometimes referred to as blood sugar) to rise too high.
There are two major types of diabetes. In type 1 (formerly called juvenile-onset or insulin-dependent) diabetes, the pancreas completely stops producing any insulin, a hormone that enables the body to use glucose found in foods for energy. People with type 1 diabetes must take daily insulin injections to survive. This form of diabetes usually develops in children or young adults but can occur at any age.
Type 2 (formerly called adult-onset or non-insulin-dependent) diabetes results when the body doesn't produce enough insulin or is unable to use insulin properly, a condition known as insulin resistance. This form of diabetes usually occurs in people who are over 40, overweight, and have a family history of diabetes, although today it is increasingly occurring in younger people, particularly adolescents.
According to federal statistics, an estimated 18.2 million children and adults in the United States--6.3 percent of the population--have diabetes. An estimated 13 million of these people have been diagnosed, and some 5.2 million are thought to have type 2 diabetes without knowing it. Most people with diabetes have type 2; an estimated 800,000 have type 1. Diabetes is the sixth-leading cause of death by disease in the United States. The condition and its complications cost an estimated $132 billion annually in the United States alone, in terms of healthcare expenses and lost productivity.
Poorly managed diabetes can lead to a host of long-term complications, including heart attacks, strokes, blindness, kidney failure, blood vessel disease that may require an amputation, nerve damage, and impotence in men. But a nationwide study completed over a 10-year period showed that if people keep their blood glucose level as close to normal as possible, they can reduce their risk of developing some of these complications by 50 percent or more.
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Causes
Your body changes much of the food you eat into glucose, a type of sugar, which is then carried by the bloodstream to be used to power the millions of cells in your body. The cells cannot use glucose for energy without the help of insulin, a hormone made by the pancreas that helps glucose enter them. Diabetes is a disease in which the body's insulin-producing system malfunctions. Glucose then builds up to excessive levels in the bloodstream.
In type 1 diabetes, which used to be called juvenile-onset or insulin-dependent diabetes, the body completely stops producing insulin. People with type 1 diabetes must take daily insulin injections to survive. This form of diabetes usually develops in children or young adults but can occur at any age. (In type 2 diabetes, which used to be called adult-onset or non-insulin-dependent diabetes, the body produces insulin but either does not produce enough to properly convert food into energy or is not able to use the insulin it does make. This form of diabetes usually occurs in overweight people who are over 40 with a family history of diabetes.)
In type 1 diabetes, the body stops--or almost stops--producing insulin because the immune system misfires and attacks the beta cells of the pancreas, which manufactures the hormone. The causes of this autoimmune disorder aren't known, although factors relating to genetics, environment, and trauma or infection all may be involved.
Risk factors
The possible risk factors for type 1 diabetes include some that are genetic, some that are environmental, and some that are related to trauma or infection. The interplay among factors is not entirely known.
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Environmental risk factors
Evidence suggests an environmental influence is at work in determining who gets type 1 diabetes, though the relationship is unclear. Among Caucasians, diabetes risk varies geographically. In general, the risk is higher in Northern Europeans than Southern Europeans--though Sardinians in the Mediterranean also are at elevated risk. In recent decades, there has been an upswing in type 1 diabetes in the United States and Europe. While Asians generally have a much lower incidence of type 1 diabetes, Japan is also experiencing a rise in cases. Such changes are most likely linked to some environmental or behavioral factor. Possibilities include climate, exposure to some virus, and infant diet.
Temporal clusters of type 1 diabetes cases (those that occur around the same time--whether within families, a school, or a geographical region) have also prompted people to suspect an environmental agent. However, given that the development of diabetes takes many years in most cases, as the body's immune system malfunctions and begins destroying the body's insulin-producing cells, a clustering in time seems more likely due to chance than a common cause.
Genetic risk factors
If an immediate relative (parent, sibling, or child) has type 1 diabetes, one's risk of developing the disease is 10 to 20 times that of the general population. Your risk can rise from 1 in 100 to roughly 1 in 10 or possibly higher, depending on which family member has diabetes and when he or she developed it:
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If one child in a family has type 1 diabetes, siblings have about a 1 in 10 risk of developing it by age 50.
- The risk for a child of a parent with type 1 diabetes is lower if it is the mother who has diabetes than if it is the father. If the mother is 25 or younger when the child is born, the child's risk is 1 in 25, compared with about 1 in 17 when the father has diabetes. When the mother is over age 25, the risk drops to 1 in 100 -- virtually the same as for the average American. The risks are somewhat higher when a parent developed diabetes before age 11.
- About 1 in 7 people with type 1 diabetes has a condition known as type 2 polyglandular autoimmune syndrome. These people have thyroid disease, malfunctioning adrenal glands, and sometimes other immune disorders. When a parent has this syndrome, the child's risk of developing it--including type 1 diabetes--is 1 in 2, according to the American Diabetes Association.
Caucasians have a higher risk of type 1 diabetes than any other race. Whether this is due to differences in environment or genes is unclear. Even among whites, most people who are susceptible do not develop diabetes, so scientists are studying what environmental factors may be at work. Genes influencing the function of the immune system are the most closely linked to susceptibility, regardless of race. One of those genes is HLA-DR. Most Caucasians with diabetes carry gene variants (alleles) 3 or 4 (or both) of the HLA-DR gene, known as HLA-DR3 or HLA-DR4. The HLA-DR7 allele plays a role in diabetes in blacks, while HLA-DR9 allele is significant in diabetes among Japanese.
Infection- and trauma-related risk factors
Some experts believe that a trauma such as a car crash or a viral infection like mumps can trigger the onset of Type 1 diabetes. Such events increase the body's insulin requirement and strain the insulin production machinery if it is being destroyed by a malfunctioning immune system. As the demands on the body increase, they are thought to tip the body into diabetes without actually being a "cause" of the disease.
It is also theorized that a link exists between coxsackie virus, which causes meningitis, and type 1 diabetes, though the connection is unclear. Scientists do have some significant evidence that mumps does not trigger diabetes, however. A Maryland study showed that despite a great decline in mumps cases after the mumps vaccine was introduced 30 years ago, the incidence of type 1 diabetes did not change.
Some scientists believe early diet may play a role, since children who have developed type 1 diabetes are less apt to have been breastfed for a prolonged period. While some studies have pointed to exposure to cow's milk as a factor, much remains to be learned about its importance. To be prudent, mothers of infants at heightened risk of developing diabetes may want to breastfeed as long as possible and use cow's milk in moderation after the baby is weaned.
Prevention
Type I diabetes cannot be prevented. However, careful management of the disease can reduce the risk of such long-term complications as heart attacks, strokes, blindness, kidney failure, and blood vessel disease. A nationwide study completed over a 10-year period showed that if people keep their blood glucose level as close to normal as possible, they can reduce their risk of developing some of these complications by 50 percent or more.
Symptoms
The symptoms of diabetes include:
- Excessive thirst
- Frequent urination
- Weight loss
- Increased hunger
- Nausea and vomiting
- Irritability
- Extreme unexplained fatigue
Tests overview
Several different tests, most of them blood tests, are used not only to diagnose diabetes but to monitor it.
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Diagnostic tests
The American Diabetes Association recommends that all individuals age 45 and older, particularly those with a body mass index, or BMI, equal to or greater than 25, should be screened for diabetes--and if the test is normal, that they should be retested every three years. Testing should be conducted at earlier ages and carried out more frequently in individuals who have any of the diabetes risk factors.
The ADA recommends that patients should be told they have diabetes if any of the criteria below applies:
- Blood glucose levels as measured by a fasting plasma glucose test are equal to or greater than 126 mg/dl.
- Diabetes symptoms exist and glucose levels measured at random are equal to or above 200 mg/dl.
- Glucose is equal to or greater than 200 mg/dl during an oral glucose tolerance test.
- If test results indicate diabetes, testing should be repeated on a different day to confirm the diagnosis. If a random blood test has found glucose equal to 200 mg/dl or above, the confirming test used should be a fasting plasma glucose or an oral glucose tolerance test.
This section has information on screening tests for diagnosing diabetes.
Screening tests for diagnosing diabetes
Diabetes may be diagnosed using the oral glucose tolerance test (OGTT) or a fasting plasma glucose test.
The OGTT requires a fast of eight to 12 hours, after which a person's blood glucose is measured before drinking a glucose-containing solution and then again two hours later. In normal glucose tolerance, blood glucose rises no higher than 140 mg/dl two hours after the drink. In people with prediabetes or impaired glucose tolerance (IGT), the two-hour blood glucose is between 140 and 199 mg/dl. If the two-hour blood glucose rises to 200 mg/dl or above, the diagnosis is diabetes.
In the fasting plasma glucose test, a person's blood glucose is measured once after a fast of eight to 12 hours. A person with normal blood glucose has a blood glucose level below 100. A person with impaired fasting glucose has a blood glucose level between 100 and 125 mg/dl. If the fasting blood glucose level rises to 126 mg/dl or above, the person has diabetes.
The OGTT includes measures of blood glucose levels after a fast and after a glucose challenge. In 1997, an American Diabetes Association expert panel recommended that doctors use the fasting plasma glucose test to screen their patients for diabetes because the test is easier and less costly than the OGTT. On the other hand, the OGTT is more sensitive in identifying people with problems that may first appear only after high glucose intake.
Blood glucose tests
There are two major ways to monitor your diabetes: Have your A1C checked by your healthcare provider and check your own blood glucose values.
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Home blood glucose monitoring, which tells you your blood glucose level at that very moment
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A1C testing, which tells you and your healthcare provider about your blood glucose control over the past two to three months
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The fructosamine test, a tool for measuring how well your diabetes treatment program is working
Home blood glucose monitoring
Home blood glucose monitoring provides a snapshot of how your treatment is working at one moment in time, so you can better tailor your eating program and medication. It also tells you if any symptoms you are experiencing, such as sweats or feeling faint, are the result of low blood glucose (hypoglycemia), so you can treat this problem swiftly. When you are sick or under stress, careful monitoring helps you adjust your treatment program immediately to keep your blood glucose level from going too high or too low.
Your doctor or diabetes team will help you decide what type of meter to buy. Most new meters today read the glucose level as if the blood sample were plasma rather than whole blood, since that's the way results are reported by your doctor's office or lab. By having the meter record results as "plasma glucose," you and your healthcare team can more easily compare your lab tests with your home tests. Plasma numbers run 10 to 12 percent higher than those for whole blood; if your premeal plasma glucose target is 90 to 130 mg/dl, the target would be 80 to 120 mg/dl if your meter reads whole blood.
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How to test your blood glucose
In order to get an accurate blood glucose result, you need to make sure that the meter is clean, that its code matches your test strips, that your finger is clean, and that you're testing an adequate-size drop of blood. Before pricking your finger, wash your hands with warm water, shake your hands below your waist, and squeeze your finger a few times.
In order to understand what the readings mean for you, you will need to know:
- Your target blood glucose range. A range of 90 to 130 mg/dl before meals is suggested for most people with diabetes. Ask your doctor what your target range should be.
- When to check your blood glucose. Some people check two times a day every day; others check four times a day. Ask your healthcare provider for guidance.
- It's a good idea to write down your blood glucose numbers in a diary or logbook and look for patterns over time. For example, are your blood glucose readings before breakfast higher or lower than your target? Once you see patterns, you can look for causes--and avoid them.
A1C test
If home blood glucose monitoring is like a snapshot, A1C testing, handled by a lab, is more like a full-length movie; it provides an average of your blood glucose levels over a period of two to three months by measuring how much glucose has combined with the oxygen-carrying hemoglobin in your red blood cells. For people who have not undergone any major changes in their lifestyle or diabetes regimen, A1C tests offer an assessment of long-term blood glucose control. A normal reading would be 4 to 6; in people with diabetes, the target is below 7.
A terrific result does not necessarily mean that your blood glucose has been continuously under control; people with highs and lows that balance each other out could also get a great reading. This is why daily blood glucose readings are so important. A reading that falls between 7 and 8 for more than six months, or a reading over 8, suggests that the treatment plan needs to be changed.
Fructosamine test
Measuring the amount of fructosamine in the blood allows the healthcare team to assess how well controlled blood glucose levels have been over the past two to three weeks. It is often prescribed when changes are being made in a diabetes treatment plan and information is needed about how well the new plan is working.
Testing for ketones
Ketones are acids produced when the body burns fat for energy. They are also produced when you lose weight or when insulin is not available to help your body use sugar for energy. When the body is unable to use glucose for energy, it breaks down fat instead; as a result, ketones form in the blood and spill into the urine. These ketones can make you very sick.
You can test to see if your body is making ketones by doing a simple urine test. There are several products available for ketone testing that can be purchased without a prescription. Common product names include Ketostix, Chemstrip K, and Acetest. The test result can be negative or show small, moderate, or large quantities of ketones.
You should test for ketones:
- Anytime your blood glucose is over 250 mg/dl for two checks in a row.
- When you are ill. Often illness, infections, or injuries will cause sudden high blood glucose, and this is an especially important time to check for ketones.
- When you are planning to exercise and the blood glucose is over 250 mg/dl.
- If you are pregnant, you should test for ketones each morning before breakfast and anytime the blood glucose is over 250 mg/dl.
- As long as blood glucose levels are not too high, the presence of ketones is not a problem; this may occur if you are trying to lose weight.
- Untreated high blood glucose with ketones can lead to a life-threatening condition called diabetic ketoacidosis (DKA). If the ketone test is positive, call your diabetes educator or physician to see if you need more insulin, and drink plenty of water and noncaloric fluids to "wash out" the ketones. Continue testing your blood glucose every three to four hours, testing for ketones if the blood glucose is over 250 mg/dl. Do not exercise if your blood glucose is over 250 mg/dl and ketones are present.
Treatment overview
There is as yet no cure for diabetes. But when a treatment plan results in blood glucose levels that are normal or nearly so, a person's risk of developing complications drops dramatically.
There are certain things that you need to do religiously in order to be healthy: Take insulin injections, follow a meal plan, and be physically active (physical activity can help the body better use insulin, so it can convert glucose into energy for cells). You'll have to monitor your blood glucose closely; regular testing will help determine how well the steps you're taking are working to keep blood glucose levels in a normal range. For more information, see our page on home monitoring.
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Treatment during the disease's early stages
People with type 1 diabetes must take daily insulin injections, since they produce little or none on their own. Insulin is a vital hormone that helps your body convert food into energy. Without it, glucose builds up to intolerable levels in the bloodstream; untreated, patients die.
But in the early stages, shortly after diagnosis, many patients experience a "honeymoon period" during which insulin needs are minimal; some people can actually maintain normal or near-normal blood glucose taking little or no insulin. This occurs because at this point in the disease's progression, a small percentage of the body's insulin-producing cells are still in operation. The disease may even appear to go away, since symptoms may emerge when the patient has an illness, then subside along with the illness as insulin needs decrease.
But the process that has destroyed most of the insulin-producing cells will ultimately destroy the remaining cells.
Meal planning
Your body changes much of the food you eat into glucose. The amount of blood glucose that comes from your diet is important, because your dose of insulin will be calibrated to match the amount of food that you eat every day. If you eat more food than usual without an insulin adjustment, you will have high blood glucose (hyperglycemia). If you eat less food than usual, you will have low blood glucose (hypoglycemia).
When you eat is also important. Your meals and medication work together so that your body can use the sugar from the food for energy or store it for a later time. A dietitian can help you formulate a meal plan.
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Carbohydrate counting
One way people with diabetes can manage their food intake to keep their blood glucose as close to normal as possible is by calculating how many grams of carbohydrate they eat. Carbohydrates tend to have the greatest effect on blood glucose.
The balance between the amount of carbohydrate you eat and the available insulin determines how much your blood glucose level goes up after meals or snacks. To help control your blood glucose, you need to know which foods contain carbohydrate, the size of a "serving" of different foods, and how many carbohydrate servings to eat each day. There's no magic number of daily servings that's right for everyone; instead, it is important to work with a dietitian to determine what will work for you. By checking your blood glucose, you can see whether changes are needed. If your levels are too high, for example, you may need to eat fewer carbohydrate servings, be more physically active, or work with your diabetes team to adjust your insulin.
Foods that contain carbohydrate include grains, pasta, and rice; breads, crackers, and cereals; starchy vegetables such as potatoes, corn, peas, and winter squash; legumes such as beans, peas, and lentils; fruits and fruit juices; milk and yogurt; and sweets and desserts. Nonstarchy vegetables such as broccoli, salad greens, and green beans are very low in carbohydrate.
Carbohydrate counting can ensure that the right amount of carbohydrate is eaten at each meal and snack. Likewise, insulin may be adjusted based on what the person wants to eat. For example, if you want to eat a much larger meal, this approach can help you determine how much extra insulin to take.
Portion control
The amount of food you eat is closely related to blood glucose control. If you eat more food than is recommended on your meal plan, your blood glucose goes up. Although foods containing carbohydrates have the most impact on blood glucose, most foods will have some effect.
The only way you can tell if you are eating the right amount is to measure your foods carefully:
- Practice, practice, practice. Don't rely on measuring once and then just "guesstimating." Pull out the scales at least once a week to check yourself.
- Use a glass that you know holds only 4 or 8 ounces. You can also place a piece of tape on the outside of a glass to mark off a serving.
- A bread serving is based on a 1-ounce slice of bread. Many single bread servings may weigh more than 1 ounce and therefore have more impact on blood glucose. Check labels of such items as light breads, bagels, or rolls.
- Know the weight of fruit servings for portion control.
- Check your cereal portion using measuring cups.
Alcohol consumption
The use of alcohol should be discussed with your physician and healthcare team. As a general guideline, people using insulin can have two alcoholic beverages in addition to their regular meals, but no food should be omitted in exchange for an alcoholic drink.
Some alcoholic beverages are higher in sugar and carbohydrates: sweet wines, sweet vermouth, and wine coolers, for example. Use these sparingly.
When making the decision about whether to use alcohol, you should understand what the potential effects of alcohol are on your health. Although alcohol has little effect on blood glucose control, it may worsen other medical problems. Make sure you discuss the use of alcohol with your doctor. Here are some general guidelines:
- With your doctor's approval, alcohol should be limited to two drinks a day. A "drink" is defined as a 12-ounce beer (preferably light beer); a 4-ounce glass of wine; a 2-ounce glass of dry sherry; or 1.5 ounces of a distilled beverage, such as whiskey, rye, vodka, or gin.
- Even though your doctor may approve the use of alcohol, you may want to avoid the extra calories if you are trying to lose weight.
- Alcoholic beverages can make your blood glucose drop. Avoid the risk of low blood glucose by having your drink at mealtime, or having a snack along with the drink.
- Avoid drinks that contain large amounts of sugar.
- Drink with caution, and carry identification that says you have diabetes. Signs of low blood glucose are similar to those of intoxication. Make sure your companions know how to treat an insulin reaction.
Insulin injections
There are several types of insulin, classified by how soon and how long they act. It is helpful to know when the insulin you take starts to work, its peak (when the insulin is working its hardest), and the duration (how long the insulin works). Premixed combinations of slower- and fast-acting insulins are also available.
- Rapid-acting insulins include insulin aspart (Novolog) and insulin glulisine (Apidra). They begin to act in 10 to 30 minutes and reach their peak in 30 minutes to three hours, and their effects last between three and five hours.
- Short-acting insulin is regular insulin. It begins to work in 30 to 60 minutes, peaks in one to five hours, and lasts as long as eight hours.
- Intermediate-acting insulins such as NPH begin working in between one and four hours. They peak at between four and 12 to 15 hours, and last up to 26 hours.
- Long-acting, peakless insulins include insulin glargine (Lantus), which begins working in between one and two hours, does not peak but has consistent effects, and lasts as long as 24 hours.
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Insulin pumps
An insulin pump is a small, computerized device that delivers insulin continuously throughout the day. It attempts to mimic the normal pancreas's release of insulin, but you must tell the pump how much insulin to inject. It delivers insulin in two ways: a basal rate, which is a continuous, small trickle of insulin that keeps blood glucose stable between meals and overnight, and a bolus rate, which is a much higher rate of insulin taken before eating to "cover" the food you plan to eat.
Effective, safe use of the pump requires a commitment to checking blood glucose at least four times a day, counting carbohydrates, and adjusting your insulin doses based on blood glucose levels, carbohydrate intake, and physical activity.
The main advantages of pump therapy are increased flexibility of lifestyle; predictable and precise insulin delivery; the ability to accurately deliver one tenth of a unit of insulin; tighter blood glucose control, while reducing the risk of low blood glucose; reducing episodes of severe hypoglycemia; reducing wide fluctuations in blood glucose, and helping manage the "dawn phenomenon" (the early-morning rise in blood glucose).
The main disadvantages of pump therapy are risk of skin infections at the catheter site; risk of diabetic ketoacidosis (DKA) from pump malfunction or absorption problems; the cost; and the need to check blood glucose at least four times per day.
Hints for storing and using insulin
To make sure your insulin is safe and effective:
- Store unopened bottles in the refrigerator and do not use after the expiration date. Don't freeze them.
- Store bottles you are using at room temperature (59 to 86 degrees Fahrenheit) for 28 to 30 days. The strength of the insulin may be altered after that.
- Avoid exposing the bottles to temperature extremes (less than 36 degrees Fahrenheit or more than 86 degrees Fahrenheit).
- Don't use regular insulin if it becomes cloudy in appearance.
- Don't use NPH if it becomes clumped or crystallized or if the bottle becomes frosted.
- Make sure that you recheck your dosage whenever you change insulin.
- Get guidance from your healthcare team before mixing insulins or prefilling syringes.
Weight gain
Taking insulin is often associated with weight gain, which can prompt people to cut back on their insulin intake. Causes for the weight gain include:
- People who have poorly controlled diabetes sometimes experience weight loss because their bodies are unable to properly convert food into energy. Taking insulin helps reverse that process and can result in a weight gain.
- When blood glucose runs high, you can become dehydrated as your body works to clear itself of all that excess glucose. Getting your blood glucose under better control may cause you to retain fluid.
- Once you start taking insulin injections, glucose in your blood can get into the body's cells and be used rather than remaining in your bloodstream and being excreted in your urine.
- High blood glucose may cause people to feel hungry and eat more, because not all the food taken in can be properly processed to nourish the cells. Frequently, eating patterns continue after insulin has been started and is allowing more-efficient use of nutrients.
Some people cut back on their insulin once they discover they can lose a few pounds quickly by doing so. But when they go back to using the right amount of insulin, they discover that they gain the weight back--and perhaps more--in equally rapid fashion. Manipulating insulin to lose weight is an unhealthy habit to get into. Letting your blood glucose run high can lead to long-term complications. Better to make careful adjustments in how much you eat.
Managing overview
Everyone who has diabetes should be seen at least once every six months by an endocrinologist or a diabetologist and periodically by other members of a treatment team, including a diabetes educator and a dietitian, who will help develop or refine a meal plan. Ideally, you should also consult an exercise physiologist about a physical activity plan and, perhaps, a social worker, psychologist, or other mental health professional for help with the stresses of living with a chronic disease. It's extremely important to see an ophthalmologist annually, so any eye problems can be treated before they become serious.
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Diabetes burnout
Diabetes burnout is a common patient reaction to the overwhelming, demanding, and frustrating burden of self-care: You know that reasonable care is important for your health, but you just don't have the motivation to continue to be vigilant when it seems that blood glucose fluctuations are inevitable anyway.
How to get back on track?
- Remember that success depends upon having realistic, practical, and achievable goals. Define one action you could take to start to improve your situation--preferably a fairly easy action that makes success likely.
- If a specific obstacle keeps getting in your way, try to concretely define it. When, where, and why does the problem occur? Consider changing your behavior or your environment, either to make handling the issue easier or to avoid it.
- Consider: Are there other people who could help you? Moral support at home, at work, and in social situations can make a big difference. Decide what kind of support you need and then ask.
- Understand that strong negative feelings about diabetes are normal. Talking with family, friends, health professionals, and other people with diabetes about your feelings can help you to better tolerate them and react in constructive, rather than self-destructive, ways.
- Keep your eye on the rewards of good care, not the consequences of failure. Fears about complications may motivate you for a short time, but in the long run most people either dismiss their fears or become paralyzed by them. Rather, focus on how great you've felt when you've managed the disease well.
"Sick day" guidelines
When people with diabetes are sick with a cold or the flu, or are vomiting, or recovering from surgery, their blood glucose will often be higher than usual--even if they are eating less food. This is because insulin is often less effective during an illness or after an injury. Talk to your healthcare provider about how to manage your disease when you're not feeling well. In general, the following "sick day" steps should be taken to keep blood glucose under control:
- Take your usual insulin even if you can't eat normally, unless your healthcare provider instructs you differently. In some cases, additional insulin is required.
- Check your blood glucose every three to four hours, including during the night. Have someone do it for you if you are too sick to do it yourself.
- Check for ketones if your plasma blood glucose is 250 mg/dl or higher, unless otherwise instructed by your healthcare team.
- Write the results of your blood glucose and ketone checks down and have them ready if you need to call your healthcare provider.
- Drink plenty of fluids--about 6 to 8 ounces every hour you are awake. If you are able to eat your meals, drink fluids that are sugar free and caffeine free. If you are unable to eat, alternate sugar-free fluids one hour with fluids containing sugar the next. Include liquids with salt, too, such as bouillon or clear soup.
- Rest. Stay warm.
Call your healthcare provider if:
- you are vomiting or have diarrhea for more than two hours,
- you have a fever,
- your blood glucose values remain above 250 mg/dl for at least two checks or do not decrease with extra insulin (whether or not you have ketones),
- you have stomach pains that won't go away.
Complications of Diabetes (Type 1)
Developing complications from diabetes is not inevitable. The nationwide Diabetes Control and Complications Trial, completed in the mid-1990s, showed conclusively that people with type 1 diabetes could reduce their risk of complications by as much as 50 percent if they keep their blood glucose level as close to normal as possible. The recent United Kingdom Prospective Diabetes Study found similar results for people with type 2 diabetes.
What's the target for blood glucose control in someone with diabetes? Ideally, an A1C test, which indicates how well your blood glucose levels have been controlled over the past two months or so, should produce a reading of below 7. If your results are hovering nearer to 8 or even higher, it's time for a change in your treatment plan.
The hemoglobin A1C test is an average of your blood glucose levels, so a weakness is that frequent fluctuations between too high and too low can result in a misleading reading. Therefore, it's also important that you routinely measure your blood glucose levels at home. In general, plasma blood glucose results that are over 180 mg/dl two hours after eating or above 140 mg/dl before eating are considered high. If your blood glucose remains high for three days or more, an adjustment in your treatment plan may be required to prevent complications.
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Neuropathy
Chronically high blood glucose levels can cause nerve damage, or neuropathy. This often results in pain in the extremities--the legs and feet, for example. Over time, the pain can subside and be replaced by numbness, as nerve damage becomes nerve cell death.
When the damaged nerves influence how well your stomach and intestines clear food through your system, a condition called gastroparesis develops; symptoms can include abdominal discomfort, nausea, vomiting, and bloating. Nerve damage in other areas of the body might mean incomplete emptying of the bladder, incontinence, or sexual dysfunction. Damage to nerves that regulate blood flow and blood pressure can cause significant drops in blood pressure--and lightheadedness or fainting--when you sit or stand.
If you begin to show signs of neuropathy, the most important first thing you can do is to try to prevent further damage by making sure your blood glucose is under control. Sometimes, improving blood glucose control can lessen symptoms of neuropathy over time, even as it's helping to prevent further damage. Nerves do not grow back, however. Once pain is replaced with numbness--a sign the nerves are dead--the numbness will not go away.
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Managing the pain of neuropathy
People with neuropathy often find the discomfort very difficult to tolerate. Some patients find relief by keeping blood glucose as closely controlled as possible, experiencing regular physical activity, and keeping their weight under control. Doctors may suggest aspirin, acetaminophen (Tylenol), or drugs containing ibuprofen. Using these nonnarcotic pain relievers consistently throughout the day--rather than waiting until nighttime when symptoms can become more severe--seems to help if pain is the major symptom. Narcotic painkillers are not very effective and can be addictive.
One of the most commonly used and effective medications is gabapentin (Neurontin), which has relatively few side effects. A topical cream (capsaicin) may help relieve the pain of neuropathy by blocking nerve signals. An analgesic ointment such as Bengay may also help.
Surprisingly, clinicians have found that certain antidepressants seem to be effective at helping patients tune out their pain. Antidepressants can take several weeks to work, so patients should wait a month before deciding whether a drug is helpful or not.
Some patients have experienced success with other forms of pain management--biofeedback, meditation, hypnosis, and acupuncture, for example.
Sexual dysfunction
Some people with diabetes experience sexual problems, because out-of-control blood glucose levels can lead to blood vessel and nerve damage that hampers performance and enjoyment. While this is particularly true in older men who have had diabetes for years, many medical experts believe that women with diabetes experience sexual difficulties as a result of complications of the disease.
Other factors can cause or exacerbate sexual dysfunction, including self-consciousness and fear of failure. If you are experiencing impotence or sexual dysfunction, it's important to see your doctor for an accurate diagnosis of your condition. People who experience sexual difficulties can lead more enjoyable, fulfilling sex lives by learning about causes, treatment options, and how to discuss their feelings and needs with a doctor and partner.
Heart disease
People with diabetes are at greater risk of developing cardiovascular disease, or problems with the heart and blood vessels, for two reasons. First, high blood glucose levels thicken the walls of the blood vessels and make them less elastic. Second, people with diabetes tend to have higher fat levels in their blood. These fats, or lipids, clog and narrow the blood vessels. Any blood vessel in your body can become narrow and clogged, and this can lead to a heart attack, angina (heart pain), stroke, or painful legs. Women with diabetes are just as likely as men to have a heart attack or stroke.
There's no certain way to avoid heart disease and circulation problems. But there are things to do to cut your risk:
- If you smoke, stop.
- Lose weight if you are overweight.
- Keep your blood pressure in the proper range.
- Be physically active.
- Keep your blood fats and cholesterol levels in a healthy range.
- Keep your blood glucose under control.
Foot care
Over time, diabetes can damage the nerves and narrow the blood vessels of the feet, causing a lack of feeling and poor circulation--and breaks in the skin that can lead to infection. You might not experience pain, for example, if you step on a pebble or develop a blister. Your legs may hurt when you walk, and any cuts may heal slowly. Your feet may get red when you're walking or white when propped up on a chair.
You can lower your chances of developing foot problems by treating your feet gently:
- Wash your feet in warm, soapy water every day. To avoid drying out your skin and getting cracks, don't soak your feet or use hot water, and choose mild soap. Towel off carefully, including between the toes.
- Apply lotion, but not between the toes. Put talcum powder on your feet if they sweat.
- Check every day for dry skin, cracks, or cuts, and inform your doctor if you find cuts that are not healing. If you cannot easily inspect your feet, use a mirror or ask for help.
- File your toenails with an emery board, rounding the edges. Do not use scissors. Get assistance if you do not see clearly.
- See a doctor to determine the best treatment for corns and calluses. Never cut them.
- See a foot doctor regularly if you have poor circulation, nerve damage, or thick toenails.
Starting an exercise program
Before beginning an exercise program, get your doctor's clearance. A medical OK is absolutely imperative if you are 35 or older or have had diabetes for 10 years or more. Your blood glucose must be adequately controlled at the outset to produce the desired results.
An exercise program should be individually tailored and designed to complement your lifestyle. Many factors--such as the time of day you exercise or the type and duration of your exercise--will determine whether adjustments should be made in your insulin dose or your meal plan. Discuss your exercise program with your exercise physiologist to determine the type of adjustments you need to make.
Some tips on exercise:
- If you are over 35, you may need a stress test before beginning to exercise regularly.
- Test your blood glucose before and after exercise.
- Do not exercise if blood glucose is over 250 mg/dl and there are ketones in your urine. If no ketones are present, do not exercise if blood glucose is 300 mg/dl or more.
- Plan exercise to prevent low blood glucose reactions. That means you want to exercise one to 1½ hours after eating, check blood glucose before and after exercise, always carry a carbohydrate snack with you (glucose tablets, juice, etc.), and drink plenty of fluids.
High blood glucose after physical activity
When you exercise, your muscles need added glucose as a source of energy. In response to the demand from your exercising muscles, your liver pours an extra supply into your bloodstream. Remember, however, that the glucose can't be used by your muscles without the help of insulin to "unlock the door" to muscle cells; if insulin available isn't sufficient, your blood glucose levels can actually increase right after exercise.
To avoid problems:
- Check your blood glucose before exercising. Do not exercise if the reading is over 250 mg/dl and you have ketones.
- If the reading is 300 or more but no ketones are present, retest within five or 10 minutes of beginning your exercise program. It's OK to carry on if the blood glucose is dropping. If not, stop exercising.
Low blood glucose after physical activity
A common cause of low blood glucose is too much physical activity without compensating for it. In fact, moderate-to-intense exercise may cause your blood glucose to drop for the next 24 hours. This post-exercise hypoglycemia is often referred to as the "lag effect" of exercise.
When you exercise, the body uses two sources of fuel to generate energy: glucose and free fatty acids--or fat. The glucose, stored in the body in a form called glycogen, comes from the blood, the liver, and the muscles. During the first 15 minutes of exercise, most of the glycogen is drawn from the bloodstream or the muscles. After 15 minutes of exercise, the body is fueled more by glycogen stored in the liver; and, after 30 minutes of exercise, by the free fatty acids.
The body will replace its depleted glycogen stores, but this process may take four to six hours, or even 12 to 24 hours when the physical activity has been intense. During this period, a person with diabetes is at higher risk for hypoglycemia--though there are precautions that can prevent it:
- Check your blood glucose before exercising to make sure your blood glucose is sufficient. If necessary, eat an appropriate snack.
- Avoid exercise at the peak of your insulin action.
- Avoid late-evening exercise. Exercise should be completed two hours before bedtime.
- Avoid alcohol before or immediately after exercise.
- Avoid hot tubs, saunas, and steam rooms directly after exercise. Otherwise, your heart rate will remain elevated longer, and your blood glucose may continue to drop.
- Check with your doctor about the length, intensity and duration of your planned exercise program.
- Check your blood glucose immediately after exercise to prevent low blood glucose from occurring hours after exercise. It may also be necessary to check your blood glucose more often for two to four hours after exercise. Intense exercise may cause your blood glucose to drop for the next 24 hours.
What should you do if you find your blood lucose is less than 100 mg/dl immediately after exercise?
- Follow post-exercise snack guidelines. If you are not scheduled for a snack or a meal for 30 to 60 minutes after exercise, 15 grams of carbohydrateshould be sufficient to prevent a low blood glucose. If no meal or snack is scheduled for more than one hour, take 15 grams of carbohydrateand 7 to 8 grams of protein.
- Increase carbohydrate intake before exercise.
- Decrease the dose of active insulin for the next exercise session.
- Consider decreasing the insulin dosage following exercise.
- If your blood glucose at bedtime is still less than 100 mg/dl, double your bedtime snack, or if possible, decrease your bedtime insulin dose.
Unplanned exercise
Sometimes exercise or physical exertion occurs spontaneously, so that preparation isn't possible. You may need extra carbohydrate (or an insulin adjustment, or both) at these times to make sure you have the sufficient energy. A number of factors will determine what you need:
- Snacks may be necessary for exercise beginning two hours or more after your last meal.
- You may need a snack if you exercise for an hour or more.
- Long-duration or all-day activities may require both a snack adjustment and an insulin adjustment.
- If you are attempting to lose weight, plan your exercise so you can limit the amount of extra food needed to keep your blood glucose from dropping too low.
Pregnancy
It's eminently possible for a woman with diabetes to have an uncomplicated pregnancy and a healthy baby these days--as long as she is willing to be vigilant about controlling her blood glucose levels. Glucose levels that are too high put both mother's and baby's well-being at risk.
You'll want to prevent an unplanned pregnancy; your goal is to conceive after your blood glucose levels have been well controlled for several months. During the earliest weeks of fetal growth, the risk of birth defects is heightened if blood glucose levels are not in control.
During pregnancy, your dietary and insulin needs are bound to change as your body does. It'll be even more vital than usual to get good medical care and nutritional guidance.
Problems that may arise
Sometimes your blood glucose may become high even when you are feeling well and taking good care of yourself. When that happens and ketones are present, you may become very sick with an illness called "DKA," or "diabetic ketoacidosis." Your blood glucose may also become too low, in which case you may have an insulin reaction.
This section contains information on:
Hyperglycemia (high blood glucose)
People who do not have diabetes typically have blood glucose levels that run under 126 mg/dl, measured two hours after eating. Your physician will define for you what your target blood glucose should be--identifying a target as close to normal as possible that you can safely achieve given your overall medical health. Be sure to ask your healthcare provider what he or she thinks is a safe target for you for blood glucose before and after meals.
In general, high blood glucose, also called hyperglycemia, is reached when the level is 160 mg/dl, or when it is above your individual target. If your blood glucose is high for long periods of time, you run an increased risk of complications over the long term: eye disease, kidney disease, heart attacks, and strokes, to name a few. High blood glucose can pose health problems in the short term as well. Your treatment plan may need adjustment if your blood glucose stays over 180 mg/dl for three days in a row.
Symptoms of high blood glucose include increased thirst, increased urination, dry mouth or skin, tiredness or fatigue, blurred vision, more frequent infections, slow-healing cuts and sores, and unexplained weight loss.
High blood glucose can be caused by too much food; too little exercise or physical activity; poorly calibrated treatment; or illness, infection, injury, or surgery.
What should you do if you have hyperglycemia?
- Be sure to drink plenty of water.
- If your blood glucose is 250 mg/dl or greater, check your urine for ketones. If they are present, call your healthcare team, as you may need additional insulin.
- Ask yourself what may have caused the high blood glucose, and take action to correct it. Ask your healthcare team if you are not sure what to do.
- Check your blood glucose before meals three days in a row. If it's higher than your target level for three days, a change in your treatment plan may be needed.
Hypoglycemia (low blood glucose)
Low blood glucose, or hypoglycemia, is one of the most common problems associated with insulin treatment. In general, hypoglycemia is defined as a blood glucose level below 70 mg/dl (if your meter tests whole blood) or 80 mg/dl or lower (if, like most new meters, it tests plasma), or below 90 mg/dl if you have symptoms. Be sure to ask your healthcare team what would be considered a low blood glucose requiring treatment for you.
Hypoglycemia is usually unpleasant, with the most common symptoms being shakiness and sweatiness and having one's heart pound. The most common reasons for hypoglycemia are too much insulin, too little food, or too much activity. Another cause is drinking alcoholic beverages. Most hypoglycemia, if quickly and appropriately treated, it is more of an inconvenience than a cause for alarm.
However, severe hypoglycemia can cause mental confusion, antagonistic behaviors, unconsciousness, and seizures. The biggest danger is not the condition itself but what may happen as a result: a motor vehicle accident caused by passing out at the wheel or swerving into oncoming traffic, or a tumble down the stairs, for example. In rare cases, seizures can result in brain damage.
To avoid problems with hypoglycemia:
- Recognize the symptoms, which are specific to each individual and may change over time. If you have symptoms, test immediately if possible to see if your blood glucose is low.
- Understand the interaction between food intake, treatment, and physical activity so you can anticipate when hypoglycemia is a risk.
- Always carry carbohydrates for treatment. Don't overdo it: The most common error is to overtreat low blood glucose.
- Check blood glucose levels again in 15 minutes, and repeat treatment if symptoms persist or blood glucose levels have not risen above your target level.
- Check blood glucose levels before driving if you think you may be low--and stop the car immediately if you're already underway. Treat immediately with the appropriate amount of fast-acting carbohydrate. Check blood glucose levels again in 15 minutes and do not start driving again until you're no longer hypoglycemic.
Diabetic ketoacidosis (DKA)
When the body cannot use sugar for energy, it uses stored fat. Acids known as ketones may build up in the blood and spill into the urine when fat is burned for energy; when blood sugar is also high, a life-threatening medical emergency called diabetic ketoacidosis, or DKA, can result.
You may develop DKA quickly if you are sick, so it's important to check your blood every four hours when you have an illness or infection. You may also get DKA slowly, however. Check for ketones whenever your blood sugar is 250 or above. More information is available at Testing for ketones.
If you are getting DKA, you may:
- Have to urinate a lot
- Be extra thirsty or hungry
- Feel sleepy
- Feel weak
- Vomit for an extended time
- Have stomach pains
- Have chest pains
- Breathe hard
- Experience confusion
- Call your doctor immediately or go to the emergency room if you develop symptoms.
Hyperosmolar hyperglycemic state (HHS)
Some people develop very high blood glucose and become very ill without also developing ketones. This type of illness, which is more common in type 2 diabetes but can occur in people with type 1, is called hyperosmolar hyperglycemic state. It may be caused by several factors, including an infection, some medications, or poor self-care and is marked by severe dehydration.
Call the doctor if your blood glucose is 250 mg/dl or higher for more than two readings and you:
- Are urinating more frequently than usual
- Are excessively thirsty
- Feel ill
- Have a fever
- Feel sick to your stomach or are throwing up
- Experience confusion or vision impairment
Travel
Travel is fine--as long as you don't take a vacation from watching your health. When you are preparing for a trip:
- Ask your doctor for a green light.
- Get a letter from your doctor that says you have diabetes. You may need it if you are ever challenged for having syringes and medications with you.
- Get prescriptions for syringes and medicines. You will need them if you lose your supply.
- If you will be traveling across time zones, check with your medical team to find out what that will mean for your insulin intake and eating schedules.
- Ask your doctor for names of other physicians along your route.
- Get any necessary shots a month before you travel. When you pack, carry medical necessities (plus extras) and snacks in a small travel bag--and then, when you travel, keep it with you at all times.
- Take along all the syringes that will be needed during your trip. Pack alcohol to wipe off the tops of insulin bottles. Take a glucagon kit and your monitor and strips to check your blood for glucose. Bring foot-care supplies.
- Store insulin so that it is neither too cold (below 35 degrees) nor too hot (above 90 degrees).
On the road:
- Carry a card that says you have diabetes. It should include your name, address, and phone number; your doctor's name and phone number; and the kind and dosages of all medications you take. Wear a bracelet or necklace with the same information on it.
- Do not skip meals or snacks. Keep food with you to treat an insulin reaction. Pull off the road if you have a reaction while driving.
- Check your blood glucose more often. Match the amount of food you eat and your medication dose with your activity. You will need more food for walking, swimming, or skiing than for sitting in movies. Follow your meal plan and exercise program when traveling.
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